b-complex vitamin

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J Am Geriatr Soc. 1991 Mar;39(3):252-7.

B complex vitamin patterns in geriatric and young adult inpatients
with major depression.
==================================================================

Bell IR, Edman JS, Morrow FD, Marby DW, Mirages S, Perrone G, Kayne HL,
Cole JO.

McLean Hospital Geriatric Service, Harvard Medical School, Belmont,
Massachusetts.

This study compared the B complex vitamin status at time of admission
of 20 geriatric and 16 young adult non-alcoholic inpatients with major
depression. Twenty-eight percent of all subjects were deficient in B2
(riboflavin), B6 (pyridoxine), and/or B12 (cobalamin), but none in B1
(thiamine) or folate. The geriatric sample had significantly higher
serum folate levels. Psychotic depressives had lower B12 than did
non-psychotic depressives. Poorer blood vitamin status was not
associated with higher scores on the Hamilton Depression Rating Scale
or lower scores on the Mini-Mental State Examination in either age
group. The data support the hypothesis that poorer status in certain B
vitamins is present in major depression, but blood measures may not
reflect central nervous system vitamin function or severity of
affective syndromes as measured by the assays and scales in the
present study.

PMID: 2005338 PubMed - indexed for MEDLINE

Publication Types, MeSH Terms, Substances
-----------------------------------------

Publication Types:

Research Support, Non-U.S. Gov't

Research Support, U.S. Gov't, Non-P.H.S.

MeSH Terms:

Adult

Aged

Aged, 80 and over

Blood Proteins/metabolism

Depressive Disorder/blood

Female

Folic Acid/blood

Humans

Male

Middle Aged

Nutritional Status/physiology

Riboflavin Deficiency/blood

Serum Albumin/metabolism

Vitamin B 12 Deficiency/blood

Vitamin B Complex/blood

Substances:

Blood Proteins

Serum Albumin

Vitamin B Complex

Folic Acid

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FOLIC ACID - HSDB

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Biol Psychiatry. 1990 Jan 15; 27(2):125-37.

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 pathophysiological consequences

Z Gerontol Geriatr. 2004 Apr; 37(2):109-35.

Z Gerontol Geriatr. 2004

» See reviews...  » See all...

Cited by 4 PubMed Central articles
----------------------------------

Understanding nutrition, depression and mental illnesses.

Rao TS, Asha MR, Ramesh BN, Rao KS. Indian J Psychiatry. 2008 Apr;
50(2):77-82.

Indian J Psychiatry. 2008

Intake of B vitamins in childhood and adult life in relation to
 psychological distress among women in a British birth cohort.

Mishra GD, McNaughton SA, O'Connell MA, Prynne CJ, Kuh D. Public
Health Nutr. 2009 Feb; 12(2):166-74. Epub 2008 May 27.

Public Health Nutr. 2009

ReviewNutritional therapies for mental disorders.

Lakhan SE, Vieira KF. Nutr J. 2008 Jan 21; 7:2. Epub 2008 Jan 21.

Nutr J. 2008

» See all...

Patient drug information
------------------------

Folic Acid (Folvite®)

Folic acid is used to treat or prevent folic acid deficiency. It
is a B-complex vitamin needed by the body to manufacture red blood
cells. A deficiency of this vitamin causes certain types of anemia
(low red blood cell c...

Thiamine

Thiamine is a vitamin used by the body to break down sugars in the
diet. The medication helps correct nerve and heart problems that
occur when a person's diet does not contain enough thiamine.

Pyridoxine

Pyridoxine, vitamin B6, is required by your body for utilization
of energy in the foods you eat, production of red blood cells, and
proper functioning of nerves. It is used to treat and prevent
vitamin B6 deficiency resu...

Source: AHFS Consumer Medication Information

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