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--------------------------------------------------------------------- March 30th, 2010
FDA Shoots Down New Combo Heart Drug ------------------------------------ What medication are you looking for? Find it now!
Today in London the FDA decided to postpone approval of a new experimental heart drug, seeking more information about the new product. The drug called Certriad, combines AstraZeneca’s blockbuster cholesterol pill Crestor with Abbott Laboratories TriLipix.
According to Rueters, The manufacturers said on Tuesday they had received a so-called “complete response letter” from the U.S. Food and Drug Administration for Certriad, which combines Astra’s blockbuster cholesterol pill Crestor and Abbott’s TriLipix.
Both companies said they were evaluating the letter from the agency and would respond to the request for additional information. An AstraZeneca spokesman declined to give further details. Combo pills are fairly common for heart drugs, and most thought that FDA approval was a given. Merck merged Zocor and Zetia to form Vytorin, and soon they plan to combine Zetia with Pfizer’s Lipitor.
Combo pills are also fairly common in diabetes drugs. For example Januvia, Avandia,and Actos are all available as combo product with generic versions Glucophage. In typical big pharma fashion, Astra did not disclose what the FDA has a problem with, but many analysts have voiced concern that Certraid does not have enough backing to pass FDA approval after the results from a clinical study this month showed there was no real benefit from adding TriLipix to Crestor.
Posted by Cary Byrd in AstraZeneca, Crestor, Lipitor, Prescription drugs, Zocor, hypertension.→ No CommentsTechnorati Tags: AstraZeneca · Crestor · Lipitor · Prescription drugs · Zocor · hypertension If you enjoyed this post, you might also like:
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“C-reactive protein”: soon, the world will know your name (thanks to Crestor) ---------------------------------------------------------------------
March 23rd, 2010 Leader in Heart Medicine Dies at 85 -----------------------------------
beta blockers Leader in Heart Medicine Dies at 85 Sir James Black, a leader and pioneer in heart medicine died Sunday at the age of 85. Black was a Nobel piece prize pharmacologist who’s breakthrough work saved a countless number of lives.
Sir James’s was responsible for the discovery of the drugs propranolol and pronethalol — which work by blocking the body’s own response to stress hormones. Black changed the way doctors approached helping heart patients. “One of the few things that really deserves the moniker ‘Landmark’,” said Dr. Clyde Yancy, the president of the American Heart Association. “Easily millions of patients have been helped with beta-blocking therapies.”
Beta blockers shot out beta receptors in organs like the heart and lungs. They reduce the effect of excitement/physical exertion on heart rate and the force of contraction. Some common beta blockers used today are: acebutolol, betaxolol, bisoprolol, propranolol, atenolol, labetalol, carvedilol, metoprolol, and nebivolol.
Doctors have found that the use of beta blockers in heart attack patients has significantly lowered the chance of death, and thanks to Sir James Black, they are also used to help remedy abnormal heart rhythms, anxiety, angina, headaches and high blood pressure. For more of Sir James Blacks personal story, check out this story.
He will certainly be missed and the work he leaves behind will continue to help in the lives of many. Posted by Cary Byrd in Prescription drugs, beta blockers.→ No CommentsTechnorati Tags: Prescription drugs · beta blockers
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--------------------------------------------------------------------- March 16th, 2010
What Allergy Medication Can Help You? ------------------------------------- allergy medication What Allergy Medication Can Help You?
As some may know all too well, allergy season is about to hit full swing. Instead of sniffling and sneezing your way through the season, lets take a look at some types of medications that may help remedy your allergy problem. The 2 different types of allergy medications we will look at are antihistamines and leukotriene modifiers.
Antihistamines Antihistamines work by blocking receptors for histamine. Histamine is a chemical produced by your body that reacts to certain allergens like pollen, mold, dust mites or pet dander. Certain symptoms that could be relieved by using a antihistamine are nasal congestion, itching, and sneezing.
Current antihistamines don’t cause as much drowsiness as they have in the past, but still can cause mild sleepiness in some users. One great thing about antihistamines is that they can be taken on a regular basis without experiencing significant side effects. Claratin, Allegra, Astelin, Clarinex, and Zyrtec are all common drugs found in the antihistamine category. Leukotriene Modifiers
Leukotriene modifiers are used to treat both allergies and some types of asthma by blocking leukotriens from their receptors. Leukotrienes are fatty molecules found in the immune system. Like antihistamines, luekotriene modifiers also don’t have many side effects and can be taken regularly. Here are some commonly known Leukotriene modifiers: Singulair, Accolate, and Zyflo CR.
Some of these allergy medications can be bought over the counter, but those who suffer from allergies should see a doctor for a correct diagnosis as to what type of medication would suit them. Make sure to order your prescription drugs through eDrugSearch.com to avoid overpaying for your allergy medication.
Posted by Cary Byrd in Allergies, Drug costs, Prescription drugs.→ No CommentsTechnorati Tags: Allergies · Drug costs · Prescription drugs If you enjoyed this post, you might also like:
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Leader in Heart Medicine Dies at 85 ---------------------------------------------------------------------
March 5th, 2010 Viagra is turning 12 — get out your party hats! -----------------------------------------------
viagra 11 300x179 Viagra is turning 12 get out your party hats! We came across these interesting promotional materials (click the image to enlarge) for Viagra today, so we thought we’d share them. Even though the party blowers mark Viagra’s 11th birthday, by our calculations the drug turns 12 on March 27, 2010 — the anniversary of its FDA approval.
What medication are you looking for? Find it now! Posted by Cary Byrd in Prescription drugs, Viagra.→ No CommentsTechnorati Tags: Prescription drugs · Viagra
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eDrugSearch.com attends Consumer Reports health summit Some material on the eDrugSearch Blog may not be suitable for children under 13
--------------------------------------------------------------------- March 1st, 2010
Reid Smith, 2, is fighting kidney cancer and needs your help ------------------------------------------------------------
- Year Old Reid Smith Reid Smith, 2, is fighting kidney cancer and needs your help
One of our local Bulverde, Texas Firefighters, Ruben Smith has a two year old son Reid Smith who is fighting stage 3 kidney cancer. They are not able to remove his kidney as the other kidney is too weak, so they are starting chemo therapy. Ruben and his family will have many out-of-pocket, co-pays and other expenses and your prayers are greatly needed. Ruben and his wife have three children including a baby recently born in 2009. If anyone can help with a donation it would mean the world to this family along with your prayers – I STRONGLY BELIEVE IN THE POWER OF PRAYERS!! Let’s help those who normally help others!
Anyone can send a donation to the Bulverde/Spring Branch EMS station to help the family offset some expenses. You can also send gift cards, gas cards for traveling, dine out cards, grocery store cards, frozen meals…anything you think will help is needed. Here is the Reid Smith Tax Deductible Number EIN# 80-0549713
You can make the check out to Ruben Smith. Please send the check and/or other charitable items to:
Bulverde/Spring Branch ATTN: Reid Smith PO Box 38 Spring Branch, Tx. 78070 Hang in there buddy…our prayers and help is on the way!
Jeremiah 33:6 (New International Version) says: “Nevertheless, I will bring health and healing to it; I will heal my people and will let them enjoy abundant peace and security.” Posted by Cary Byrd in Cancer, Prescription drugs.→ 1 CommentTechnorati Tags: Cancer · Prescription drugs
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--------------------------------------------------------------------- February 22nd, 2010
Neglected high blood pressure a leading cause of death in the U.S. ------------------------------------------------------------------ high blood pressure hypertension Neglected high blood pressure a leading cause of death in the U.S.
According to a report recently released by the Institute of Medicine, hypertension (high blood pressure) has become the second leading cause of death for people in the US. Although hypertension is easily preventable through diet, exercise and drugs, it claims one in six lives in the United States, costing our health care system upwards of 73 billion dollars this last year.
The committee chair David Fleming, who directs Public Health for Seattle and King County in Washington said Hypertension as a disease is relatively easy to diagnose and it’s inexpensive to treat. Hypertension is really a neglected disease in this country. There’s a huge gap between what we could do and what we are doing.
Simply reducing salt and implementing a diet with more fruits, vegetables and lean protein could lower high blood pressure by as much as 22 percent, the Institute says. Doctors typically use drugs like beta blockers (Lopressor, Toprol XL, Inderal) and ACE inhibitors (Captopril, Ramipril, Accupril) to control blood pressure. Lowering blood pressure can cut the risk of heart attack, stroke, heart failure as well as many other conditions.
The report went on to point out that 86 percent of people with uncontrolled high blood pressure have insurance, and see their doctors regularly. Flemming stated that doctors often fail to follow guidelines, which is why many patients do not know they have the condition and and take no steps to try and control it. Don’t fall into this category, make sure to check with your doctor and make sure that your blood pressure is in a healthy range.
Of the many things that you may neglect, don’t allow your health to be one of them. Posted by Cary Byrd in Prescription drugs, hypertension.→ 2 CommentsTechnorati Tags: Prescription drugs · hypertension
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--------------------------------------------------------------------- February 15th, 2010
Diabetes drug may be a little fishy ----------------------------------- metformin fishy smell Diabetes drug may be a little fishy
New studies released today found that many who take the popular diabetes medication metformin find the odor off-putting, and some have trouble taking the medication. The “fishy” odor is especially noticeable in the immediate release versions.
“Metformin is an excellent drug, but the immediate-release formulation may have an odor to it. The smell is fishy or like the inside of an inner tube, and in a patient’s mind, because it smells like something that has gone bad, they may think the drug isn’t good,” explained one of the letter’s authors, J. Russell May, a clinical professor at the University of Georgia College of Pharmacy at the Medical College of Georgia. However, May said, “some metformin products on the market are extended-release and the drug is embedded and released slow, over time. These products have much less smell, if any.”
May and his colleagues wrote the letter to the journal to raise awareness of this issue, especially because nausea is a commonly reported side effect of metformin. “Is it nausea from the medication, or is it because it smells bad?” May said. The drug’s odor may make it seem like it has gone bad, but doctors have reassured patients that it is just something in the formula of the medication, and the drug is still affective at treating diabetes and is not dangerous.
Bristol-Meyers Squib who is one of the major producers of metformin released a statement saying, Bristol-Myers Squibb is aware that the inherent characteristics of metformin have been associated with a mild odor upon opening of the bottle, so these type of reports are not unexpected. It’s important to note there has been no correlation between an odor and the efficacy of metformin, which has been on the market in the U.S. since 1995.
Some of the brand versions of metformin that may give off this “fishy” odor are: Glucophage, Glumetza, Fortamet, and Riomet. Patients prescribed metformin should continue on their regular regiment, but should certainly let their doctor know if they are affected by the smell. They may be able to switch to the extended release version or possibly another brand.
Posted by Cary Byrd in Bristol-Myers Squibb, Diabetes, Metformin, Prescription drugs.→ 1 CommentTechnorati Tags: Bristol-Myers Squibb · Diabetes · Metformin · Prescription drugs If you enjoyed this post, you might also like:
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Is Januvia worth the price? ---------------------------------------------------------------------
February 8th, 2010 Big Pharma making big cuts in R&D ---------------------------------
According to reports, the axe is coming down all over the pharma world on research and development projects that are not yielding immediate results. AstraZeneca(Atacand, Crestor), GlaxoSmithKline (Advair, Boniva) and Pfizer (Benadryl, Lipitor) have all already begun to scrap projects, while others like Sanofi-Aventis (Allegra, Plavix) are about to pick up the trend and start making cuts.
The cuts come as no surprise, as big pharma companies have been seeing there pipelines shrink since 1998, when the trend to buy out drug rights from smaller bio-tech companies began. Despite the increased cost efficiency of buying drugs from smaller bio-techs, I am not so sure that big pharma is going to like the end result of their decision.
Stephen Foley raises some excellent questions in a recent post, saying those calculations about the benefits of in-licensing over in-house could change rapidly if the competition for licensing deals, which has been getting more ferocious for several years, increases dramatically. It could be that they will regret swinging cuts to their R&D budgets sooner rather than later.
And there is another reason for executives to pause. There are very great political benefits from drug companies being able to trumpet the life-changing discoveries that have emerged from their research labs and their scientific trials. Yes, these are companies that have manipulated the publication of scientific data, made over-reaching claims for their drugs, and practiced price gouging of government health and insurance services, but they are also companies that lower our cholesterol, shrink tumors, keep diabetes in check and lift the burdens of depression. In the UK, there is an explicit compact with the government on this score: drug prices charged to the National Health Service are set to allow for investment in research. In the US, the good works of drug research help keep in check the demands for re-importation of drugs from lower-priced Canada, and other cost-cutting measures. It sounds like big pharma is trying to have their cake and eat it too; outsourcing research and development to cut costs while still maintaining control over patents on drugs to protect their profits.
Cutting the cost of research and development is like cutting off your leg to lose weight. Why not cut the fat of advertisement out first. After all, aren’t doctors suppose to tell us the medicines we need? After they get rid of the cost of research and development, what excuse will big pharma have left to overcharge consumers?
Posted by Cary Byrd in AstraZeneca, Big Pharma, GlaxoSmithKline, Pfizer, Pharmaceutical companies, Prescription drugs, Sanofi-Aventis.→ 1 CommentTechnorati Tags: AstraZeneca · Big Pharma · GlaxoSmithKline · Pfizer · Pharmaceutical companies · Prescription drugs · Sanofi-Aventis If you enjoyed this post, you might also like:
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Big Pharma shifts more of its marketing online ---------------------------------------------------------------------
February 1st, 2010 Mixing herbal supplements and heart medications may be dangerous ----------------------------------------------------------------
heart medications Mixing herbal supplements and heart medications may be dangerous According to a report from Reuters, taking ginkgo biloba, St. John’s wort and several other widely used herbal medications may impede the potency of prescription drugs, making them more or less effective.
Experts at the Journal of the American College of Cardiology found that mixing herbs and drugs also may cause serious heart rhythm problems and bleeding. “We can see the effect of some of these herb-drug interactions — some of which can be life-threatening — on tests for blood clotting, liver enzymes and, with some medications, on electrocardiogram,” Dr. Arshad Jahangir of the Mayo Clinic in Arizona said in a telephone interview.
Many patients fail to disclose their use of herbal remedies so healthcare providers should be more probing, Jahangir said in a telephone interview. “We need to be actively ask about alternative or complementary medicine patients may be seeking on their own to assess these potential interactions or side affects,” said Jahangir, a cardiologist.
“They don’t even consider that herbs could have a negative effect,” he said. “Their impression is that ‘natural’ is safe,” So whether you use an ACE inhibitor like Vasotec or Monopril, alpha agonists like Zanaflex, or angiotensin II receptor blockers like Avapro or Atacand, it is a good idea to check with you doctor and make sure there won’t be an interaction with any of the additional supplements you may be taking.
Remember, whenever dealing with potential interactions between medicines and supplements, it is always better to error on the side of caution. Better safe than sorry.
Posted by Cary Byrd in Drug safety, Medical information, Prescription drugs.→ 1 CommentTechnorati Tags: Drug safety · Medical information · Prescription drugs If you enjoyed this post, you might also like:
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Seniors must be vigilant about drug interaction risk ---------------------------------------------------------------------
January 25th, 2010 New multiple-sclerosis drug approved by the FDA -----------------------------------------------
FDA Ampyra pil multiple sclerosis new New multiple sclerosis drug approved by the FDA Today the Food and Drug Administration approved Ampyra, a new drug owned by Biogen Idec. to fight multiple sclerosis.
The new drug is an extended-release tablet aimed at helping to increase mobility in those battling against multiple sclerosis. The FDA said those who took the drug had better movement and faster walking speeds than those who had taken a placebo. “For people with MS, impaired walking ability is one of the most common and concerning aspects of the disease,” said Alfred Sandrock, senior vice president of neurology research and development at Biogen Idec, in a statement. “Ampyra may be an important therapy in reducing the impact of this debilitating condition.”
The drug is set to be marketed by Acorda Therapeutics Inc. who also is responsible for marketing Zanaflex. Despite its usefulness to help mobility is those suffering from MS, the FDA did warn that Ampyra, when given at doses greater than recommended, can cause seizures. However, the FDA did not feel that a “black box” warning on the label of the drug was necessary, which is the most serious type of warning for potential side effects.
Posted by Cary Byrd in Prescription drugs, Prescriptions.→ No CommentsTechnorati Tags: Prescription drugs · Prescriptions If you enjoyed this post, you might also like:
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Why pharmaceutical companies want marijuana legalized ← Previous Entries
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