Information about damage from lipitor
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Legal Briefs ------------ Lipitor, Other Statins May Permanently Damage Muscle Tissue, New Study Finds ----------------------------------------------------------------------
Lipitor and other cholesterol-fighting drugs called statins are taken by millions of Americans to prevent heart disease, but the class of drugs can cause permanent muscle damage long after patients stop taking them, new research says. About 10 to 15 percent of people taking Lipitor and other statins a recent study reported suffering minor muscle aches and weakness while a smaller percentage of patients experience myopathy, which is lingering, stronger pain, according to the study’s authors.
Other popular brands of statin drugs include Zocor, Pravachol, Lescol, and Crestor. The drugs are among the best-selling drugs in the United States, earning their makers about $14.5 billion in sales in 2008. Study Finds Moderate to Severe Muscle Damage
Researchers from the University of Bern in Switzerland focused on leg muscle tissue taken from 83 patients. Of those studied, 44 were taking statins and had serious, persistent muscle pain, 19 were taking statins but has no myopathy, and 20 were not taking statins and did not suffer from myopathy. Of the 44 statin patients who suffered myopathy, 29 were still taking a statin at the time of the examination, while 15 had stopped taking the drug at least three weeks prior. Using biopsies of muscle tissue, researchers determined that 25 of the 44 patients with myopathy had muscle damage.
However, the research does also include a curious medical mystery of sorts. Only one patient in the study had high levels of creatine phosphokinase (CPK), an enzyme which when found in the blood can be a sign of muscle damage. Researchers said their findings of muscle damage in statin users without elevated levels of CPK challenges long-held conventional wisdom that low levels of CPK in the blood rules out the possibility of muscle damage. Researchers said based on their new findings, it is possible to see microscopic muscle damage even when levels of CPK in the blood are normal.
Lingering Muscle Damage Noted Perhaps most troubling of the new statin study is the finding that muscle damage caused by the drugs can linger long after the patient stops taking them.
Most patients with muscle damage symptoms recovered quickly after stopping the drugs, but some developed what is called myotoxicity and suffered persistent structural injury, researchers said. The new study is the latest to link use of statins to muscle damage. In September 2008, a study presented at a meeting of the American Physiological Society concluded that statins can interfere with the body’s ability to repair damaged muscle tissue. In that study, patients taking Zocor were less able to multiply or heal new muscle cells.
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Permalink This entry was posted on Monday, July 6th, 2009 at 4:53 pm and is filed under Legal Briefs. You can follow any responses to this entry through the RSS 2.0 feed. Both comments and pings are currently closed.
« First Drug for Advanced Lung Cancer Earns FDA ApprovalsKroger’s Flavored Popcorn Products Recalled Amid Salmonella Fears » One Response to “Lipitor, Other Statins May Permanently Damage Muscle Tissue, New Study Finds”
1. Alanna Garman Says: I completely and wholeheartedly agree with this. Quite a few years ago, not exactly how long, 7 or 8 years maybe, I was put on Lipitor for 6 months when my thighs started to hurt. I called the doctor and he said to go ahead and stop. They did a blood test and all levels were fine. I have had moderate to severe pain in my thighs since. I have since lost massive amounts of sleep, they ache during the day, and at night the pain is worse. Sometimes just an ache sometimes so extremely bad only a heating pad helps relieve the pain. I generally will take advil or excedrin PM to help me get through the night so I can get some sleep. I’ve tried a lot of different methods to help this and so far unsuccessful. My mom has had the same reaction as I had. I’m completely frustrated with the medical field as they do not see the link and they just want to give me more medications to help with the pain. Forgetting that pain is your body telling you that something is wrong. I was actually thinking about trying to find a doctor to do a muscle biopsy when I stumbled on this article. I hope to find something to help reverse the damage, but sleep is suppose to be a way for the body to repair itself and now I lose that. Although I’m not quite sure this is going to be reversible. Thanks for posting this article, it eases my mind a bit.
July 12th, 2009 at 11:17 pm Legal Briefs
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