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venlafaxine Index
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GENERIC NAME: venlafaxine

BRAND NAME: Effexor, Effexor XR
DRUG CLASS AND MECHANISM: Venlafaxine is in a new class of
anti-depressant medications that affects chemical messengers within
the brain. These chemical messengers are called neurotransmitters, and
some examples are serotonin, dopamine, and norepinephrine.
Neurotransmitters are manufactured by nerve cells and are released by
the cells. The neurotransmitters travel to nearby nerve cells and
cause the cells to become more or less active. Many experts believe
that an imbalance in these neurotransmitters is the cause of
depression and also may play a role in anxiety. Venlafaxine is
believed to work by inhibiting the release or affecting the action of
these neurotransmitters.  Venlafaxine is available in an extended
release formulation (Effexor XR).

PRESCRIPTION: Yes
GENERIC AVAILABLE: Yes

PREPARATIONS: Effexor is available in tablets of 25, 37.5, 50, 75, and
100 mg. Effexor XR is available in capsules of 37.5, 75, and 150 mg.
STORAGE: Store in a dry place at 20-25°C (68-77°F).

PRESCRIBED FOR: Venlafaxine is prescribed for the treatment of
depression, depression with associated symptoms of anxiety,
generalized anxiety disorder, and social anxiety disorder. Effexor XR
is approved for the treatment of adults with panic disorder.
DOSING: Venlafaxine should be taken with food at doses specifically
directed by a physician. Individual doses vary greatly among
individuals. The anti-depressant effects are not maximal for 1-2
weeks. If discontinued, the dose of venlafaxine should gradually be
reduced under the direction of a physician. For patients with
difficulty swallowing tablets or capsules, capsules of Effexor XR can
be opened and the contents sprinkled on a spoonful of applesauce.

DRUG INTERACTIONS: Life-threatening interactions can occur in
combination with MAO inhibitors such as Nardil and Parnate. MAO
inhibitors and venlafaxine should not be taken together, and a waiting
period of 14 days between taking these two classes of medications is
strongly advised.
Most medications affecting the brain such as venlafaxine have the
potential to slow reflexes or impair judgment. Therefore, caution is
advised especially early in the course of treatment.

Safety has not been established in children below the age of 18 years.
PREGNANCY: The effects of venlafaxine on the fetus are unknown.

NURSING MOTHERS: It is not known if venlafaxine is secreted in milk
and, therefore, if it may have an effect on nursing infants.
SIDE EFFECTS: Venlafaxine, like most anti-depressants, can cause
nausea, headaches, anxiety, insomnia, drowsiness, and loss of
appetite. Increased blood pressure can occur, and blood pressure
should be monitored. Seizures have been reported.

"If anti-depressants are discontinued abruptly, symptoms may occur
such as dizziness, headache, nausea, changes in mood, or changes in
the sense of smell, taste, etc. (Such symptoms even may occur when
even a few doses of anti-depressant are missed.) Therefore, it is
recommended that the dose of anti-depressant be reduced gradually when
therapy is discontinued."
Reference: FDA Prescribing Information

Last Editorial Review: 1/10/2006
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venlafaxine, Effexor
Anxiety »

Introduction to Anxiety
Generalized anxiety disorder (or GAD) is characterized by excessive,
exaggerated anxiety and worry about everyday life events with no
obvious reasons for worry. People with symptoms of generalized anxiety
disorder tend to always expect disaster and can't stop worrying about
health, money, family, work, or school. In people with GAD, the worry
often is unrealistic or out of proportion for the situation. Daily
life becomes a constant state of worry, fear, and dread. Eventually,
the anxiety so dominates the person's thinking that it interferes with
daily functioning, including work, school, social activities, and
relationships.

What Are the Symptoms of GAD?
GAD affects the way a person thinks, but the anxiety can lead to
physical symptoms, as well. Symptoms of GAD can include:

Excessive, ongoing worry and tension
An unrealistic view of problems

Restlessness...
Read the Anxiety article »

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