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What is Seroquel?

Seroquel Quetiapine belongs to a group of antipsychotic drug. It
influences certain receptors in the brain. It works by diminishing the
action of dopamine and serotonin, two chemicals in the brain.

Indication

Quetiapine is used for the treatment of schizophrenia and bipolar
disorder (manic depression) in adults and children. This drug is also
used in conjunction with antidepressant drugs to treat major
depressive disorder in adults.

Dosage

The usual dosage range for adults in schizophrenia is 300 to 400
milligrams a day, divided into two or three smaller doses. The lowest
dose of this drug is 150 milligrams a day which can be increased to
highest 750 milligrams per day. To treat bipolar mania, a standard
dosage ranges from 400 to 800 milligrams a day for adults. Your doctor
may increase the dosage gradually over 4 to 6 days. For adults a
standard dose of 300 milligrams once a day at bedtime has been
recommended to treat bipolar depression, which can be slowly increased
over 4 days.

Patients having liver problems should start at 25 milligrams a day.
The doctor will raise the dose as required to 50 milligrams a day
depending on your body's reaction.

A lower dosage should be recommended in patients who are weak,
elderly, or prone to low blood pressure reactions.

Over Dosage

If the drug is taken in excess, it will have serious consequences. If
such occurs, seek medical help without delay.

Administration

Seroquel should be used as instructed by your doctor. Follow the label
on the drug for exact dosing information. This drug needs to be taken
with or without food. Continue the drug until the full course is
finished. Avoid suddenly discontinuing Quetiapine without first
consulting with your health care professional.

Before Using Seroquel

If this drug is used some medical conditions may cause problem. You
should tell your physician if you a history of heart problems, blood
vessel problems, stroke, dementia, alzheimer disease, or trouble
swallowing, or you are very overweight, high blood cholesterol levels,
or high or low blood pressure. This drug also should not be used if
you are pregnant, planning to become pregnant, or are breast-feeding.
You must inform your heath care provider about history of blood
problems, liver problems, cataracts, thyroid problems, narrow-angle
glaucoma, neuroleptic malignant syndrome (NMS), seizures, high blood
prolactin levels, or breast cancer.

Side Effects

Adverse effects with this drug are exceptional. It may give rise to
abdominal pain, diminished movement, constipation, dizziness, dry
mouth, drowsiness, excessive muscle tone, indigestion, headache, low
blood pressure (especially upon standing), neck rigidity, nasal
inflammation, rapid or irregular heartbeat, sleepiness, rash, tremor,
weakness and uncontrollable movements.

Drug Interaction

Some drugs may interact with Quetiapine. The patient must notify his
health care professional if he is taking any other drugs, particularly
any of the following: HIV protease inhibitors, Barbiturates,
alpha-blockers (eg, doxazosin) or medicine for high blood pressure,
azole antifungals, fluvoxamine, macrolide antibiotics, or
telithromycin, carbamazepine, phenytoin, corticosteroids (eg,
prednisone), rifampin, or thioridazine, dopamine receptor agonists or
levodopa.

Precaution

Seroquel may result in tardive dyskinesia, a condition showing
uncontrollable muscle spasms and twitches in the body and face. This
problem can be lasting, and is most common among older adults,
particularly women.

Antidepressants may cause suicidal thinking and behavior in children
and teenagers. So patients taking antidepressants should be observed
closely for changes in moods or actions, especially when they first
start treatment or when their dose is increased or decreased.

Contact the doctor right away if the patient develops hostility,
anxiety, insomnia, restlessness, and thoughts about suicide or dying
or impulsive or dangerous behavior. This drug is not permitted for use
in pediatric patients.

Contraindication

Seroquel is contraindicated in patients who are allergic to any
ingredient in Quetiapine or elderly patients with dementia (including
Alzheimer's disease).

Contact your health care professional right away if any of these apply
to you.

Storage

Store the drug at room temperature.

Synonym

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