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DrRich
Introduction to the Covert Rationing Blog

The Grand Unification Theory of Healthcare
How Important Is Cholesterol, Really?
=====================================

Posted on January 24, 2008
Filed Under Cardiology Topics 
In addition to being the Rabble-Rouser-In-Chief for this fine blog and
its groundbreaking parent website, DrRich for several years has also
been the cardiology expert at About.com. (About.com is a New York
Times company, but since his association with About.com predates that
of the NYT, DrRich sincerely hopes that his more conservative readers
will not hold this against him.) In this capacity, DrRich routinely
tries to clarify for his readers (who are mainly patients with heart
disease and their loved ones), controversial topics in heart disease.
Because cardiologists (like all theologians) never tire of arguing
over how many angels can dance on the distal pole of a defibrillation
lead, and because the popular media delights in reducing these arcane
arguments to breathless (and commonly misleading) headlines, there is
a never-ending cascade of material upon which DrRich can draw.

Most recently, the results of a clinical study called ENHANCE has had
many in the popular media (in response to new concerns voiced by
medical experts), questioning the deeply-entrenched cholesterol
paradigm - that is, the idea that LDL cholesterol (the bad kind of
cholesterol) is indeed bad, and that anything we can do to lower it is
good. Questioning the cholesterol paradigm - a belief system we’ve all
been taught since we were babes in arms - is deeply disturbing,
confusing and troublesome to many American patients (judging, at
least, from the response DrRich has received from readers of his heart
disease site).
These patients have been told for years to arrange their lives around
the reduction of their cholesterol levels. And while the proportion of
people who actually do so does not exceed the proportion who, in
earlier times and under a different paradigm, actually arranged their
lives so as to further their odds of spending eternity in paradise
(modern sinners often preferring instead to rely on today’s equivalent
of the deathbed conversion - the stent), the sudden notion that the
cholesterol god is dead leaves these patients unbalanced, uncentered
and oddly empty. They are also beginning to believe that their
doctors, who (some appear to be saying) have been preaching a false
doctrine at them for many decades, are even more full of crp than
previously thought.

In response to this existential crisis, and so as to fulfill his
duties to About.com and its parent company, DrRich has posted an
article that purports to place all this in perspective, and more
importantly, to give patients some guidance as to how to proceed in
regard to their cholesterol therapy NOW (i.e., during the next 10
years or so, while the experts debate the issue, and argue over
whether the current guidelines - the following of which doctors will
continue to be paid-to-perform - actually make sense.)
Normally, DrRich would not trouble readers of the Covert Rationing
Blog with topics pertaining to his other duties. But this recent
cholesterol controversy has already attracted the attention of other
medical bloggers he admires, some of whom have offered (for instance,
here and here) very level-headed opinions on the matter. Frankly,
while DrRich is clearly very comfortable pontificating on matters
related to healthcare reform (and most other topics), he gets nervous
touching on theology or its close relative, cholesterology. So DrRich
will be very interested to know from readers of this blog if his
advice - which, again, is aimed at American patients - seems
sufficiently clear, and most of all, reasonable. The posting can be
found here.

Thank you for your indulgence.
cholesterol ENHANCE about.com

Comments
  1. Responses to “How Important Is Cholesterol, Really?”
1.  A Skeptic on January 24th, 2008 8:04 pm

I would like to hear your views on the current practice of
prescribing lipid lowering therapy to “goal”. Wouldn’t it make
more sense just to identify the high risk patient by baseline LDL
level, prescribe a high potency statin at the highest tolerated
dose, and just continue it indefinitely with perhaps occasional
LFT’s but no other repeated laboratory testing? Do we gain
anything other than a better number by adding additional drugs
(niacin, fibrates, etc.)which add additional potential toxicity? I
think this is the more important question. I don’t think there’s
any evidence-based answer.
2.  DrRich on January 24th, 2008 8:57 pm

Skeptic,
Most of the studies done with statins actually did not aim for a
specific cholesterol goal, but instead simply randomized patients
to a fixed dose of a statin (usually a “high” dose) vs. some other
treatment. The cholesterol treatment goals that are talked about
in the guidelines, as nearly as I can tell, were derived from the
cholesterol levels achieved in such trials. This is logical if the
therapeutic benefit is actually related to the post-therapy
cholesterol level. But if the therapeutic benefit is actually due
to the cumulative effects of the statin, then that benefit would
be achieved, as you suggest, without ever measuring a follow-up
cholesterol level.

The fact that we don’t know the answer to this question has less
practical import than you might think, since, if higher doses of
statins are used, in general the reduction in cholesterol levels
will hit the “target” in any case. Using drugs other than statins
rarely comes in to play, practically speaking, unless statins are
not tolerated, or unless niacin is added to further increase HDL
levels.
More commonly docs will start with a low statin dose, then measure
cholesterol levels to see if more statin is needed in order to hit
the target cholesterol level. If docs started with the higher
doses of statins used in the clinical trials, your strategy would
probably work out just fine in the majority of patients.

DrRich
3. Dr. Val on February 3rd, 2008 6:26 pm

I thought your summary article was great. Thanks for taking the
time to put it all together. :)
4.  MichaellaS on July 20th, 2009 9:30 am

tks for the effort you put in here I appreciate it!
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