Information about high active vitamin d
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Release Date: Feb. 10, 2010 Expiration Date: Feb. 10, 2011 Estimated time for completion: 15 minutes There is no fee for this activity.
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Learning Objectives Upon successful completion of this educational program, the reader should be able to: 1. Discuss the results of this study 2. Review the relevance and significance of the study in the broader context of clinical care Disclosures Todd Neale , Robert Jasmer, MD; Associate Clinical Professor of Medicine, University of California, San Francisco, and Dorothy Caputo, MA, RN, BC-ADM, CDE, Nurse Planner, have disclosed that they have no relevant financial relationships or conflicts of interest with commercial interests related directly or indirectly to this educational activity.
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Specialty: AAN: High Intake of Vitamin D Linked to Lower MS Risk =====================================================
By Todd Neale, Staff Writer, MedPage Today Published: February 10, 2010 Reviewed by Robert Jasmer, MD; Associate Clinical Professor of Medicine, University of California, San Francisco and Dorothy Caputo, MA, RN, BC-ADM, CDE, Nurse Planner Earn CME/CE credit for reading medical news
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Explain to interested patients that this study could not prove a causal relationship between a mother's vitamin D intake during pregnancy and risk of multiple sclerosis, but did show an association between vitamin D intake and daughters. Note that this study was published as an abstract and will be presented at a conference. These data and conclusions should be considered to be preliminary until published in a peer-reviewed journal.
TORONTO -- Women whose mothers consumed high levels of vitamin D during pregnancy have a lower risk of developing multiple sclerosis, a large, observational study confirmed. Mothers who reported the highest intake during pregnancy were 45% less likely to have a daughter who subsequently developed the disease than those who consumed the least vitamin D (RR 0.55, 95% CI 0.35 to 0.88), according to Fariba Mirzaei, MD, MPH, a doctoral student at the Harvard School of Public Health.
Mirzaei is scheduled to report the findings at the American Academy of Neurology (AAN) meeting in April. Lily Jung, MD, a neurologist at Swedish Medical Center in Seattle, said in an interview that the study "adds more fuel to the fire that low vitamin D is important in the genesis of MS," which has been demonstrated in previous studies. (See High Blood Levels of Vitamin D May Lower MS Risk)
She said it's unclear why vitamin D is associated with risk of multiple sclerosis. "There's an idea that perhaps there might be receptors that are turned on by vitamin D levels that give some form of protection, but that is very preliminary information and we're still learning a lot about that," said Jung, who is also a spokeswoman for the AAN.
Although the link between vitamin D and risk of multiple sclerosis has been demonstrated before, gestational exposure to the vitamin has not been studied. To fill that gap, Mirzaei analyzed data from the Nurses' Mothers' Study, which includes a subcohort of the two Nurses' Health Studies that was restricted to nurses whose biological mothers completed a questionnaire in 2001 about their diet during pregnancy.
The current analysis included 35,794 nurse-mother pairs. During the 16-year study period, 199 of the nurses were diagnosed with multiple sclerosis.
In addition to a lower risk of disease among those whose mothers consumed the largest amounts of vitamin D, those whose mothers had the highest predicted serum 25-hydroxyvitamin D levels also had a reduced risk of having a daughter with the disease (RR 0.58, 95% CI 0.37 to 0.90). In an analysis of milk drinking alone, mothers who drank at least four glasses a day had a nonsignificant reduced risk of having a daughter who would develop multiple sclerosis compared with those who drank less than three glasses a month (RR 0.44, 95% CI 0.16 to 1.23).
However, there was a significant trend for lower risk of multiple sclerosis with increasing milk consumption (P=0.001). Jung noted that the study was limited by the use of questionnaires decades after a pregnancy to determine dietary intake of vitamin D.
Nevertheless, she said, "this is very consistent with what we're seeing elsewhere in terms of vitamin D in moms and the risk of MS in kids." Mirzaei did not make any financial disclosures.
Primary source: American Academy of Neurology Source reference: Mirzaei F "Gestational vitamin D and the risk of multiple sclerosis in the offspring" AAN 2010. Earn CME/CE credit for reading medical news
Related Article(s): High Blood Levels of Vitamin D May Lower MS Risk
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