Information about side effects of vitamin d supplements





 

 

 
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Vitamin D Deficency & Vitamin D Supplement
==========================================
Vitamin D Deficiency Symptoms
-----------------------------

A deficiency of vitamin D can occur when dietary intake of vitamin D
is inadequate, when there is limited exposure to sunlight, when the
kidney cannot convert vitamin D to its active form, or when someone
cannot adequately absorb vitamin D from the gastrointestinal tract .
The classic vitamin D deficiency diseases are rickets and
osteomalacia. In children, vitamin D deficiency causes rickets, which
results in skeletal deformities. Rickets results in the failure of
bone to mineralize. Children have rapidly growing bones which are most
severely affected by rickets. The growth plates of bones continue to
enlarge, but in the absence of adequate mineralization, weight-bearing
limbs (arms and legs) become bowed. In infants, rickets may result in
soft spots in the skull, and the rib cage may become deformed due to
the pulling action of the diaphragm.

The treatment of rickets includes vitamin D or calcitriol
supplementation, a diet that provides adequate calcium and phosphorus,
and a plan for the prevention of future vitamin D deficiency.
What Causes Vitamin D Deficiency in Adults
------------------------------------------

In adults, vitamin D deficiency can lead to osteomalacia, which
results in muscular weakness in addition to weak bones. Although adult
bones are no longer growing, they are in a constant state of turnover.
Bone is a dynamic tissue that is continually remodeling in response to
stress. The remodeling process involves the demineralization and
remineralization of bone through the action of bone cells called
osteoclasts and osteoblasts. In adults with prolonged vitamin D
deficiency, the collagenous bone matrix is preserved but bone mineral
is progressively lost as a result of normal bone turnover, resulting
in bone pain (in ribs, lower spine, pelvis and legs), muscle weakness
and osteomalacia (soft bones).
Vtiamin D and Your Health
-------------------------

Vitamin D and osteoporosis
It is estimated that over 25 million adults in the United States have,
or are at risk of developing osteoporosis. Osteoporosis is a disease
characterized by fragile bones. It results in increased risk of bone
fractures. Having normal storage levels of vitamin D in your body
helps keep your bones strong and may help prevent osteoporosis in
elderly, non-ambulatory individuals, in post-menopausal women, and in
individuals on chronic steroid therapy.

Researchers know that normal bone is constantly being remodeled
(broken down and rebuilt). During menopause, the balance between these
two systems is upset, resulting in more bone being broken down
(resorbed) than rebuilt. Estrogen replacement, which limits symptoms
of menopause, can help slow down the development of osteoporosis by
stimulating the activity of cells that rebuild bone.
Vitamin D deficiency, which occurs more often in post-menopausal women
and older Americans, has been associated with greater incidence of hip
fractures. A greater vitamin D intake from diet and supplements has
been associated with less bone loss in older women. Since bone loss
increases the risk of fractures, vitamin D supplementation may help
prevent fractures resulting from osteoporosis.

In a group of women with osteoporosis hospitalized for hip fractures,
50 percent were found to have signs of vitamin D deficiency. Treatment
of vitamin D deficiency can result in decreased incidence of hip
fractures, and daily supplementation with 20 mcg (800 IU) of vitamin D
may reduce the risk of osteoporotic fractures in elderly populations
with low blood levels of vitamin D. Your physician will discuss your
need for vitamin D supplementation as part of an overall plan to
prevent and/or treat osteoporosis when indicated.
Vitamin D and cancer

Laboratory, animal, and epidemiologic evidence suggest that vitamin D
may be protective against some cancers. Some dietary surveys have
associated increased intake of dairy foods with decreased incidence of
colon cancer. Another dietary survey associated a higher calcium and
vitamin D intake with a lower incidence of colon cancer. Well-designed
clinical trials need to be conducted to determine whether vitamin D
deficiency increases cancer risk, or if an increased intake of vitamin
D is protective against some cancers. Until such trials are conducted,
it is premature to advise anyone to take vitamin D supplements to
prevent cancer.
Vitamin D and Alzheimer’s Disease

Adults with Alzheimer’s disease have increased risk of hip fractures.
This maybe because many Alzheimer’s patients are homebound, and
frequently sunlight deprived. Alzheimer’s disease is more prevalent in
older populations, so the fact that the ability of skin to convert
vitamin D to its active form decreases as we age also may contribute
to increased risk of hip fractures in this group. One study of women
with Alzheimer’s disease found that decreased bone mineral density was
associated with a low intake of vitamin D and inadequate sunlight
exposure. Physicians evaluate the need for vitamin D supplementation
as part of an overall treatment plan for adults with Alzheimer’s
disease.
Vitamin D is a fat-soluble vitamin. You may have it either from
dietary or from sunlight absorbtion through skin. It absorbs and uses
calcium and phosphorus to make bone. It is essential for normal growth
and development. Finally, older individuals are at higher risk of
being deficient in vitamin D.

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