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Search << Genetic variation linked to earlier onset of Alzheimer's
symptoms  MicroRNA play a significant role in some human cancers >>
Low levels of vitamin D in men linked to heart attack
=====================================================

9. June 2008 20:03
Low levels of vitamin D appear to be associated with higher risk of
myocardial infarction (heart attack) in men, according to a report in
the June 9 issue of Archives of Internal Medicine.
---------------------------------------------------------------------

Studies have shown that the rates of cardiovascular disease-related
deaths are increased at higher latitudes and during the winter months
and are lower at high altitudes, according to background information
in the article. "This pattern is consistent with an adverse effect of
hypovitaminosis D vitamin D deficiency, which is more prevalent at
higher latitudes, during the winter and at lower altitudes," the
authors write. While other explanations are possible, vitamin D has
been shown to affect the body in ways that may influence the risk of
heart attack or heart disease.
Edward Giovannucci, M.D., Sc.D., of Harvard School of Public Health
and Brigham and Women's Hospital, Boston, and colleagues reviewed
medical records and blood samples of 454 men (age 40 to 75) who had
non-fatal heart attack or fatal heart disease from the date of blood
collection (between January 1993 and December 1995) until January
2004. They then compared the data from these men with records and
blood samples of 900 living men who did not have a history of
cardiovascular disease. The men's diet and lifestyle factors, recorded
by self-administered questionnaires were also noted.

Men with a vitamin D deficiency (having 15 nanograms per milliliter of
blood or less) had an increased risk for heart attack compared with
those with a sufficient amount (having 30 nanograms per milliliter of
blood or more) of vitamin D. "After additional adjustment for family
history of myocardial infarction, body mass index, alcohol
consumption, physical activity, history of diabetes mellitus and
hypertension, ethnicity, region, marine omega 3 intake, low- and
high-density lipoprotein cholesterol levels and triglyceride levels,
this relationship remained significant," the authors write. Men with
intermediate levels of vitamin D had a higher risk of heart attack
than those with sufficient vitamin D levels.
"Vitamin D deficiency has been related to an increasing number of
conditions and to total mortality. These results further support an
important role for vitamin D in myocardial infarction risk," the
authors conclude. "Thus, the present findings add further support that
the current dietary requirements of vitamin D need to be increased to
have an effect on circulating 25(OH)D vitamin D levels substantially
large enough for potential health benefits."

http://archinte.ama-assn.org/
2ccff995-cdf4-4292-aa73-3295cdcdcaf30.0

Posted in: Men's Health News
Tags: Cardiovascular Disease, Cholesterol, Diabetes, Diabetes Mellitus,
Diet, Heart Attack (Myocardial Infarction), Hypertension (High Blood
Pressure), Lipoprotein, Triglyceride, Vitamin D, Vitamin D Deficiency,
Vitamin E, Vitamin K

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