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VIEW ALL PRODUCTS

> Men's Health > Viagra® brand

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Viagra® brand Brand
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Manufactured: Pfizer
Active Ingredients: Sildenafil Citrate

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International Nonproprietary Name

Sildenafil citrate

Other names used:

Revatio

Indications

Erection dysfunctions (organic, psychogenic, mixed), including those
of a diabetes, adiposity, after radical prostatectomy or spinal cord
traumas.

Contra-indications

Hypersensitivity, nitrate therapy. Restrictions to application:
Serious malfunctions of liver and kidneys, anatomic deformations of a
sexual member, erythroid myeloma, acute leukemia, crescent-cellular
anaemia, increased predisposition to bleedings, hereditary pigmentary
retinitis, an aggravation of stomach ulcer and duodenal gut, heavy
forms of an arterial hypertension and a hypotonia, anamnestic
indications to the heart attack and stroke transferred in previous 6
months, life-menacing arrythmia, heart insufficiency, unstable
stenocardia, age under 18 years old.

Collateral action

Headache, dizziness, vasodilatation (inflow), hypotension, asthenia,
nasal congestion, lacrimation, malfunction of light-and colour
perception, clearness of vision, dyspepsy, a diarrhoeia, nausea,
abdominalgia, lumbodynia, arthralgia, myalgia , hypertonused muscles,
a sleeplessness, short wind, skin rash, predisposition to infection of
respiratory and urinary trackts, long painful erection (more than 4
h.).

Interaction

Strengthens orthostatic hypotension caused by nitroglycerine,
anti-aggregate effects of sodium nytroprussid. Inhibitors CYР3А4
(cinamet, ketoconazole intraconazole, erythromycin, etc.) raise
concentration in plasma, inducing substances (rifampicin, etc.) -
reduce.

Overdose

Symptoms:overdose is shown by sensation of heat, dizziness, a face
reddening, a headache, dysfunction of vision clearness, dyspeptic
phenomena, decrease of blood pressure. Treatment: symptomatic, the
dialysis is inefficient

Dosage and way of application

Inside, an hour before sexual intercourse, 50 mg. At insufficient
efficiency against good shipping the dose can be increased to 100 mg.

Special instructions

Before application for diagnostics of erection malfunction, defining
of its possible reasons and choosing of adequate methods of treatment,
it is necessary to collect the full medical anamnesis and to fulfill
careful urological and general clinical examination, especially at
patients with accompanying cardiovascular diseases for which the
raised sexual activity is undesirable (for example, heavy forms of
ischemic heart disease and hypertensive illness). Prescribing of high
doses is not recommended to elderly patients. Frequent (more than once
a day) use in high doses increases risk of side-effects. Into raised
risk category are included patients with accompanying ischemic heart
disease as renewal of an active sexual life, including the increase in
number of sexual contacts, can affect the course of the basic somatic
disease or to demand correction of medicamentous therapy. The
estimation of a parity advantage/risk is necessary at patients with
heart insufficiency, low volume of blood circulation. To prescrive
carefully to men with an arterial hypertensia ( blood pressure 170/110
mm hg) and an arterial hypotension ( blood pressure 90/50 mm hg) .
Extra carefully prescribe to patients with the accompanying arterial
hypertensia, under multicomponent hypotensive pharmacotherapy,
cautiously - at the diseases contributing to development of priapism
It is not recommended to combine with other preparations used for
treatment of erection dysfunction.

Storage conditions

At temperature not above +30°С in a place inaccessible to children.

Pharmacological action

Improving erectile function. Selectively inhibits cyclic guanosine
monophosphate (cgmPh)-dependent phosphodiesterase type 5 (Phde5),
which is contained mainly in smooth muscles of cavernous body and
prevents from destruction of (cgmPh). Level increase of the latter
leads to decreasing of endocellular concentration of calcium and to
relaxation of smooth muscle cages of cavernous body with the
subsequent increased filling of sini with blood on the background
increase in an arterial blood-flow in a sexual member and squeezing of
deferent veins. Strengthens and increases duration of erection,
resulted after sexual stimulation. Does not influence morphology,
mobility and viability of germ cells, volume and viscosity of
ejaculate. Inhibits phosphodiesterase type 6 (PhDE6) of retinas
(although weaker than PhDE5, action selectivity 10:1) and can cause
dysfunctions of colour vision. Increases antiaggregate and
de-aggregate effects of nitrogen oxydes (II) and its donors, blocks
formation of thrombi ex vivo. Expands both arterial and venous
vessels, causes decreasing of systolyc and diastolic blood pressure,
increasing of heart rate. Provides antidiuretic action. Does not
influence reproductive function, has no teratogenec, mutagen,
clastogenec (chromosomal aberrations studies) and cancerogenic
properties. When administered on an empty stomach is soaked up quickly
and almost completely. The maximum concentration in plasma will be
reached in 0,5-2 h, absolute bioavailability - 41 % (exposed to a
first-pass metabolism), fat food consummation reduces intensivity of
absorption to 11 %, the maximum concentration to 29 %. Substantially
(96 %) binds with fibers of plasma, a half-life period - 4 h. (2-8h).
It is accumulated in an organism administered 3 times a day within 9
days, cumulation makes 36 %. Up to 80 % of sildenafil metabolites are
excreted with excrements and 14 % - with urine.

More about Viagra

On recently held medical round table in Paris, the French and Italian
doctors have presented their research data, in pursuant of 85% of
patients who were taken Viagra, declare that they felt a deep
satisfaction, only 9% consider this drug insufficiently effective, and
only 2% decided to not take Viagra anymore, for fear of the side
effects.

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