Information about vitamin d and the eye
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Be the first to comment on this page US Patent 5876709 - Ophthalmic composition containing active Vitamin D ======================================================================
US Patent Issued on March 2, 1999 Estimated Patent Expiration Date: Iconsubject May 27, 2017Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent. Abstract Claims Description Full Text
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Claims What is claimed is:
1. An ophthalmic composition for preventing corneal haze/opacity and corneal refraction anomaly observed after anterior ocular tissues are damaged or due to corneal diseases, which composition is in the form of aqueous eye drops, liposomes, microspheres, proteins, collagen, and soft contact lenses, which composition comprises: a) an effective amount of at least one compound selected from the group consisting of ergocalciferols and cholecalciferols; and
b) an ophthalmically acceptable carrier. 2. An ophthalmic composition for protecting ocular tissues from harmful ultraviolet rays, which composition is in the form of aqueous eye drops, liposomes, microspheres, proteins, collagen, and soft contact lenses, which comprises:
a) an effective amount of at least one compound selected from the group consisting of ergocalciferols, cholecalciferols, an active vitamin D having a hydroxyl group on one or both of the C1 position on the sterol A ring and the C25 position on the side chain, oxacalcitriol, calcipotriol and dihydrotachysterol; and b) an ophthalmically acceptable carrier.
3. The ophthalmic composition of claim 2, wherein the active vitamin D compound having a hydroxyl group on one or both of the C1 position on the sterol A ring and the C25 position on the side chain is a compound selected from the group consisting of calcitriol (1α, 25-dihydroxy vitamin D), 1α, 24-dihydroxy vitamin D, α-calcidol (1α-monohydroxy vitamin D), calcifedol (25-monohydroxy vitamin D), 1α, 24, 25-trihydroxy vitamin D and 1β, 25-dihydroxy vitamin D. 4. An ophthalmic composition for protecting the ocular tissues from harmful ultraviolet rays, which composition is in the form of aqueous eye drops, liposomes, microspheres, proteins, collagen, and soft contact lenses, which comprises:
a) an effective amount of vitamin K; and b) an ophthalmically acceptable carrier.
5. A UV screening composition which is in the form of an ointment, lotion, cream or spray, which comprises: a) an effective amount of at least one compound selected from the group consisting of ergosterol, 7-dehydrocholesterol, pre-ergocalciferol, precholecalciferol, 1α, 24-dihydroxy vitamin D, α-calcidol, calcifedol, 1α, 24, 25-trihydroxy vitamin D, 1β, 25-dihydroxy vitamin D, oxacalcitriol, calcipotriol, dihydrotachysterol, vitamin K1, vitamin K2 and menadiol diphosphate; and
b) a topically acceptable carrier. 6. An anti-allergic composition in the form of aqueous eye drops, which comprises:
a) an effective amount of at least one member selected from the group consisting of ergocalciferols, cholecalciferols, an active vitamin D compound having a hydroxyl group on one or both of the C1 position on the sterol A ring and the C25 position on the side chain, vitamin D2 compounds, vitamin D3 compounds, active vitamin D2 compounds and active vitamin D3 compounds; and b) an ophthalmically acceptable carrier.
7. The anti-allergic composition of claim 6, wherein the active vitamin D compound having a hydroxyl group on one or both of the C1 position on the side chain is selected from the group consisting of calcitriol (1α, 25-dihydroxy vitamin D), 1α, 24-dihydroxy vitamin D, α-calcidol (1α-monohydroxy vitamin D), calcifedol (25-monohydroxy vitamin D), 1α, 24, 25-trihydroxyvitamin D and 1β, 25-dihydroxy vitamin D. 8. A composition for controlling cellular activities of intraocular tissues during an ophthalmic operation, which comprises:
a) an effective amount of at least one member selected from the group consisting of ergocalciferols, cholecalciferols, active vitamin D compounds having a hydroxyl group an one or both of the of the C1 position on the sterol A ring and the C25 position on the side chain, vitamin D2 compounds, vitamin D3 compounds, active vitamin D2 compounds and active vitamin D3 compounds; and b) a carrier acceptable for intraocular administration.
9. The composition of claim 8, wherein said ophthalmic operation is selected from the group consisting of cataract operation, intraocular lens transplantation, operation for treating corneal disease, operation for correcting corneal refraction, operation for treating glaucoma, operation for treating ocular trauma, operation for treating lens-related disease, operation for restoring retina and operation for treating lacrimal duct-related diseases. 10. The composition of claim 8, wherein component a) is selected from the group consisting of calcitriol (1α, 25-dihydroxy vitamin D), 1α, 24-dihydroxy vitamin D, α-calcidol (1α-hydroxy vitamin D), calcifedol 25-monohydroxy vitamin D), 1α, 24, 25-trihydroxy vitamin D), 1β, 25-dihydroxy vitamin D, 22-oxacalcitriol, calcipotriol, KH 1060 and dihydrotachysterol.
11. The composition of claim 8, which is in a form selected form the gorup consisting of injections to be intraocularly administered, viscoelastic substances, intraocular lenses, substitutes for vitreous bodies, tubes for intraocular transplantation and drug-sustained release agents for intraocular transplantation. Inventors ---------
Itoh, Seiji Ishii, Yasuo
Mukai, Katsuhiko Kita, Kiyoshi
Assignee -------- New Vision Co., Ltd.
Application ----------- No. 863425 filed on 05/27/1997
US Classes: ----------- 424/78.04, Ophthalmic preparation424/450, Liposomes424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)514/912OPHTHALMIC
Field of Search --------------- 424/78.04, Ophthalmic preparation424/450, Liposomes424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)514/912OPHTHALMIC
Examiners --------- Primary: Azpuru, Carlos
Attorney, Agent or Firm ----------------------- Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
US Patent References -------------------- 5622982Acylated aminoalkanimidazoles and - triazoles Issued on: 04/22/1997 Inventor: Schuster, et al.
Foreign Patent References ------------------------- WO 98/18468 WO. 05/20/1998
International Classes --------------------- A61K 009/127 A61K 009/14 A61K 031/74
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