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Vitamines - Essential Food Factors  by Benjamin Harrow
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This book is a popular presentation of a subject which concerns every
one of us; for vitamines are substances, as yet ill-defined, whose
presence in food is essential to our well-being: their absence makes
life impossible. And what more pressing problem to-day than that of
food!

Title
Vitamines - Essential Food Factors

Author
Benjamin Harrow

Publisher
E. P. Dutton & Company

Year
1929

Copyright
1929, E. P. Dutton & Company

Amazon
Vitamines, Essential Food Factors

Vitamines   Essential Food Factors
By Benjamin Harrow, Ph.D, Associate In Physiological Chemistry,
College Of Physicians And Surgeons, Columbia University

New and Enlarged Edition
Vitamines Essential Food Factors 2

To C. S. H. And M. H.
-Preface
      This book is a popular presentation of a subject which concerns
      every one of us; for vitamines are substances, as yet
      ill-defined, whose presence in food is essential to our
      well-being: their absence ...

-Vitamines. Chapter I. Introduction
      You burn a piece of wood or coal to get heat; but what makes
      your body hotter than the air outside? Why, when the doctor
      thrusts a thermometer into you, does the instrument register a
      temperature of 9...
-Chapter II. Calories
      I can buy five pounds of tea from my grocer or a quart of milk
      from the dairy; but suppose I go to my coal dealer and ask him
      for one ton of heat? He would probably look me over, then look
      at his neig...

-Food Values In Terms Of Calories
      We have seen how Lavoisier had shown that food in the body
      undergoes much the same change that coal does when it is burnt;
      in both cases there is a union with oxygen, with the ultimate
      production of c...
-The Body Furnace
      But now the reader may ask another question: If, as you say, the
      body in many ways behaves like a furnace, with food serving as
      fuel, from which heat is produced, why cannot we find out the
      amount of ...

-Man's Energy Requirements
      As a matter of fact, basing such experiments on the weight of
      the average man - about 160 pounds - the energy requirements do
      amount to about 2200 calories, provided he is resting. There
      must be grea...
-An Army's Food Requirements
      The food requirements of an army have always been the subject of
      extremely careful investigation. The following figures compiled
      during the late war are of interest for two reasons: they show
      the comp...

-Starvation
      If a body expends energy, that energy must have a source. The
      law of conservation of energy teaches us that nothing is created
      and nothing destroyed, but things do change. So if the body
      needs 3000 ca...
-Chapter III. Carbohydrates, Fats And Proteins
      We have reached the conclusion that one method of estimating the
      needs of the body is to ascertain how much heat the body
      liberates. If we assume that for the average, active individual
      the heat liber...

-The Function Of The Carbohydrates, Fats And Proteins
      As a matter of fact, each class of foodstuff has a very
      well-defined function. The carbohydrates are primarily
      energy-formers. Our muscular energy is mainly derived from the
      carbohydrates we eat. It ...
-Minimum Food Requirements
      From what has been said regarding the three classes of
      foodstuffs, it becomes evident that calories do not represent
      the sum total of nutritional requirements. Besides a sufficient
      number of calories,...

-Nitrogen Equilibrium
      There is another way of attacking the problem of protein
      requirement - a more scientific way. But before we describe
      this, a few preliminary observations become necessary. The
      reader will remember wh...
-Nitrogen Equilibrium. Continued
      The gratifying results obtained in Denmark during the war by
      feeding the people little protein diet, as suggested by Dr.
      Hindhede, look like a victory for those who urge a low protein
      diet. Unquestion...

-Chaptee IV. Mineral Matter
      When you burn a piece of coal or paper or wood you always have
      some ash left. The housewife and the stoker consider the ash
      nothing but a nuisance. It cannot be burnt and therefore is of
      no heat value...
-Calcium And Phosphorus
      The skeleton of bone largely consists of a substance to which
      chemists give the name calcium phosphate, which, judging by its
      name, evidently contains calcium and phosphorus. Here, then, we
      can point ...

-Chapter V. Water And Oxygen
      Water The struggles in life are largely struggles to satisfy
      part of our food requirements. The other part the slum dweller
      gets as easily as the owner of a Fifth Avenue mansion. That
      other part is...
-Condiments, Flavors And Stimulants
      Look into a rotisserie window and notice how it makes your mouth
      water. Making your mouth water is a fact, not a fiction.
      Psychical influences in stimulating digestion are extremely
      important, as ...

-Alcohol
      The best known, the best hated and the best loved stimulant is
      alcohol (the grain or drinking alcohol as distinguished from the
      wood alcohol). Some who see in alcohol only a substance which
      has been...
-Chapter VI. Amino-Acids
      Having surveyed rather rapidly the various substances that
      function as foods; having shown that the calorific value gives
      incomplete information; having shown the importance of a
      judicious distributio...

-Gelatin
      Early in the last century, long before a science of nutrition
      had been founded, the importance of protein in the diet was
      recognized. But so also was the recognition that protein is the
      most expensive...
-Amino-Acids
      It was subsequently discovered by Emil Fischer  and others -
      that the proteins are made up of chemical units in much the same
      way that words are made up of letters; and just as the twenty
      odd letters...

-Why Gelatin Is A Poor Type Of Protein
      But now it is time to turn back to our gelatin. A careful
      analysis of this protein has shown that two of the commonest
      amino-acids - so common that they are found in most of the other
      proteins - are m...
-The Amino-Acid Content Of Proteins
      Let us present the reader with some quantitative studies. Turn
      to page 189 and examine the percentage of amino-acids isolated
      from various proteins. What does such a list show? Some of the
      proteins d...

-Drs. Osborne And Mendel's Experiments
      They selected white rats for their experiments, for a number of
      reasons. Rats are small, easy to handle and multiply rapidly.
      They usually live not more than three years and 280 days
      suffices to comp...
-Animal And Vegetable Proteins Compared
      Now turn your attention to chart 2. A diet consisting of the
      protein casein (found in milk) which, as you may gather from
      the table in the Appendix, does not contain the amino-acid
      glycocoll, caused ...

-The Feeding Of Farm Animals
      Of equal and perhaps even more immediate consequence are these
      studies to animal production in agriculture. Let me quote Drs.
      Osborne and Mendel: Corn forms the cheapest basis for the
      feeding of farm...
-The Biological Value Of Various Proteins
      The following among the proteins so far tried, when used in
      suitable concentration, have induced normal growth in rats.
      Evidently all the essential amino-acids in suitable proportions
      are present in t...

-Chapter VII. Glycogen Or Animal Starch
      The value of a protein we have seen is specified only when
      stated in terms of its amino-acid content. The protein itself is
      complex in chemical structure, but the units out of which it is
      built, the a...
-Carbohydrates
      Let us deal with the carbohydrates first. They are chemically a
      much simpler variety of substance than the proteins. Some of
      them, such as starch and cane sugar, are, however, still too
      complicated to...

-Glycogen
      The three simple sugars, on the other hand, immediately proceed
      to the liver as soon as they are absorbed by the blood. There in
      some unknown way they are all converted to one substance,
      glycogen or a...
-The Value Of Milk Sugar In Infant Feeding
      Still, some comments are necessary. In mother's milk we find
      milk sugar. This milk sugar is found in the milk even though no
      such sugar is included in the mother's diet. Evidently then the
      milk sugar ...

-Chapter VIII. Soap And Glycerin
      The reader may wander from the heading of this chapter what a
      cleansing agent and a source for explosives have to do with the
      foods we eat. We counsel patience. Do you perhaps recall that
      story about...
-Chapter IX. Vitamines
      Milk, an excellent food for infants and growing animals,
      contains protein (casein), fat, carbohydrate (milk sugar) and
      inorganic salts. The protein if given in sufficient quantity
      contains all the nee...

-The Function Of Vitamines
      But what is the function of these vitamines? If fats and
      carbohydrates supply the fuel, and proteins the material for
      tissue supply, and mineral salts are needed for bone
      construction, etc., just what...
-The Nutritive Value Of Different Fats Compared
      Osborne, Mendel and McCollum went even further. They showed that
      while the fat from egg yolk and codliver oil, and, to a certain
      extent, beef fat, could successfully replace butter fat, neither
      olive ...

-Fat-Soluble A And Water-Soluble B
      Later on Dr. McCollum and others showed that wheat, and
      particularly yeast, was very rich in this second vitamine, which
      we shall call water-soluble B, in distinction to the first
      vitamine, which we s...
-An Adequate Diet
      From what has been said we may now formulate our revised
      conception of an adequate diet. The diet must contain, in
      addition to the long recognized dietary factors - viz.: protein,
      a source of energy ...

-Chapter X. Vitamines And Plant Growth. Auximones
      In the summer of 1912 the author well remembers how he and
      others were impressed with a remarkable lecture delivered by
      Professor Gabriel Bertrand, of the Sorbonne, Paris, on the
      effect upon the growt...
-Chapter XI. Vitamines And Beriberi
      Beriberi Symptoms Beriberi is a disease which at one time was
      particularly common among oriental people, though by no means
      unknown outside of Asia. Its final stage takes the form of a
      general paraly...

-"Polished" Rice And Beriberi
      At this point it must be explained that in the original state
      the rice proper is surrounded by a skin, the pericarp, which may
      be white, or yellow, or red, or nearly black, or any combination
      of these...
-Vitamines And Beriberi. Continued
      Diseases Due To Dietary Deficiencies In 1906, Professor Hopkins,
      a physiologist and bio-chemist said, No animal can live on a
      mixture of pure protein, fat and carbohydrate, and even when the
      necessa...

-Chapter XII. Vitamines And Rickets
      Professor McCollum's researches, described in Chapter IX
      (Vitamines), have shown us that there are at least two distinct
      vitamines, fat-soluble A and water-soluble B. The latter is
      identical with the ...
-Absence Of Fat-Soluble A Vitamine Gives Rise To Rickets
      Dr. Mellanby fed puppies with separated milk, wheat bread,
      linseed oil, yeast, orange or lemon juice and salt. They
      developed rickets within six weeks. The diet was ample in
      calorific content, Its foo...

-Chapter XIII. Vitamines And Scurvy
      Scurry is a disease that was common enough at one time among
      sailors, and often enough breaks out even to-day in
      famine-stricken districts. The symptoms may best be described by
      quoting Stefanson, the...
-Vitamines And Scurvy. Part 2
      Dr. Barlow's Treatment The cases of infantile scurvy that Sir
      Thomas Barlow describes are those of children who had never been
      breast-fed, but had received proprietary infant foods, condensed
      milk an...

-Vitamines And Scurvy. Part 3
      In this connection the clinical experiences of Drs. Hess and
      Fish are instructive. Early in 1914 an outbreak of infantile
      scurvy occurred in the Hebrew Orphan Asylum, New York. The
      infants afflicted h...
-Chapter XIV. Vitamines And Pellagra
      We no longer have any doubt that beriberi and scurvy are
      diseases due to vitamine deficiency. We still have some doubts
      regarding rickets; but the doubt here is not so much whether
      rickets results fro...

-Chapter XV. Vitamines. Summary. Practical Applications
      Instinct and experience combined guided us in our choice of food
      long before there was anything like a science of nutrition. The
      studies of our generation have confirmed what instinct and
      experience h...
-The Function Of The Vitamines
      If carbohydrates supply energy, and proteins, material for
      tissue repair, what does the vitamine supply? We really cannot
      answer this question very satisfactorily. Some liken vitamines
      to enzymes as b...

-Diseases Due To Lack Of Vitamines In The Diet
      At least two common diseases have been definitely identified
      with vitamine deficiency. One of them is beriberi, involving a
      general paralysis of the system, and due to lack of
      water-soluble B; and the...
-A Wholesome Diet
      We shall attempt to give no 101 recipes, but to draw a few
      general inferences from our discussion. In planning our diet we
      ought, wherever possible, plan it around milk as the nucleus.
      Milk, as we hav...

-Diet For The Nursing Mother
      To emphasize not merely a plentiful, but a carefully selected
      diet for the nursing mother seems almost superfluous. The
      healthy mother has not only an abundant supply of milk, but a
      milk of good quali...
-Vegetarianism
      The vegetarians who eat milk and eggs are not vegetarians,
      strictly speaking. No diet including milk and eggs is a
      deficient diet, provided always that enough of them is taken.
      Meat and fish need neve...

-Vitamines in Bread
      Next to milk perhaps the commonest of our foodstuffs is bread.
      As already stated in a discussion on cereals, bread is rich in
      carbohydrates and contains moderate quantities of proteins (see
      Appendix)....
-Vitamines in Fruit And Vegetables
      The value of these foods has already been pointed out. In this
      country we derive about 15 per cent of our total calorific value
      of the food from fruit and vegetables. This could safely be
      higher. In c...

-Vitamines in Various Food Groups
      Fish Though poor in vitamine content, fish is rich in protein
      and fat, and in that respect compares favorably with meat. Meat
      Where dairy products are plentiful - where milk and butter and
      cheese a...
-Fashion In Foods
      We must be careful in advocating certain diets to remember that
      man is not altogether a machine. The results of experiments in
      physiology and chemistry cannot always be applied in their
      entirety. You ...

-The Future of Foods
      The solution of the food problem does not rest merely with the
      physiologists and clinicians, who sort out the foods and tell us
      that one food is more wholesome than another. This is important
      enough, ...
-Appendix A. Table Of Composition And Calorie Value Of The More
Important Foods Adopted By The Interallied Scientific Food Commission
      Commodity. Protein. % Fat. % Energy value per kilo. Calories.
      Cereals - Wheat and barley flour .......... 11.5 1.0 3,640 ...

-Dr. Funk's Classification Of The Vitamines
      Antirachitic (Fat-Soluble A) Vitamine Animals that can be used
      for experimental purposes: rats and dogs (puppies). The disease
      can be induced in these animals by feeding them with a synthetic
      diet in...
-Proteins. Composition Per Cent Of Amino-Acids Isolated From Various
Proteins
      Gliadin - Rye Gliadin - Wheat Hordein - Barley Zein - Maize
      Legumin - Vetch Legumin - Cow pea Salmin - Salmon Edestin - Hemp
      Excelsin - Brazil nut ...

-The Distribution Of The Three Accessory Factors In The Commoner
Foodstuffs
      (Compiled by the British Medical Research Committee) Classes of
      foodstuff Fat-soluble A or antirachitic factor Water-soluble E
      or anti-neuritic (anti-beriberi) factor Antiscorbut...
-Some Facts Concerning Nutrition, For The Guidance Of Those Engaged In
Administration Of Food Relief To Famine-Stricken Districts
      Recent research has shown that the requirements of the human
      organism as regards diet cannot be met entirely by an adequate
      supply of protein, fat, carbohydrate, inorganic salts, and
      water. It has the...

-Distribution And Properties Of The Accessory Factors
      (1) Antineuritic Or Antiberiberi Factor (Water-Soluble B Growth
      Factor Of The Americans) This vitamine prevents the occurrence
      of beriberi in man and analogous diseases in animals. It is also
      neces...
-Practical Application Of The Foregoing Facts To The Prevention Of
Disease
      (1) Prevention Of Beriberi It is unlikely that any danger of
      beriberi will arise among the famine-threatened districts of
      Eastern Europe as long as wholemeal flour from rye, wheat,
      barley, maize, or ...

-References
      Calories The general subject of calories is treated in all
      text-books of physics. For an admirable and at the same time
      elementary treatment, R. A. Millican and H. G. Gale's Practical
      Physics (Ginn &...
-References. Continued
      Beriberi The story up to 1913 is discussed by E. P. Vedder in
      book on beriberi. C. Eijkman's classical paper appeared in the
      Archiv fur patholo-gische Anatomie, volume 149, page 197, 1897.
      Scarcely...

-Appendix B. Nutritional Experiments
      Experimental Methods During the past four years the author, in
      conjunction with Dr. Miller and Mr. Karshan, and under the
      supervision of Prof. Gies, has carried out a series of
      nutritional experiment...
-The Effect Of An Exclusive Fat Diet
      Weight on the first day: A 120 B 1254 For five days both sets
      were fed on a regular diet. At the end of the fifth day: A 129 B
      134 From now on B was fed on beef fat exclusively. On the 25
      day: ...

-The Effect Of An Exclusive Bread Diet
      Six rats per set. Weight on the first day: A 85 B 84 For four
      days both A and B were fed on the regular diets. At the end of
      the fourth day: A 97 B 98 B were now fed on bread alone. On the
      75 day:...
-The Effect Of An Exclusive Potato Diet
      Six rats per set. Weight on first day: A 71 B 73 For four days
      both A and B were fed on the regular diet. At the end of the
      fourth day: A 89 B 89 B were now fed on potatoes alone. On the
      30 day: ...

-The Effect Of An Exclusive Milk Diet (B) Using Adult Rats
      Four rats per set. Weight on first day: A 255 B 254 For three
      days both A and B were fed on the regular diet. At the end of
      the third day: A 260 B 261 B were now fed on milk alone. On the
      43 day: ...
-Comparison Of "Synthetic Diet" And "Synthetic Diet" Minus Salt
Mixture
      Six rats per set. Weight on the first day: A 76 B 80 For five
      days both A and B were fed on the synthetic diet. On the 5 day:
      A 90 B 94 From now on A was fed on the synthetic and B on the
      syn...

-Comparison Of "Synthetic Diet" And "Gelatin Synthetic Diet." Also,
The Effect Of Vitamine B (In The Form Of Yeast)
      The chapter on amino-acids (page 52) has shown that different
      proteins have not the same biological value. Casein, for
      example, is a superior protein to gelatin. In the preparation of
      synthetic diets...
-Comparison Of "Synthetic Diet" And "Synthetic Diet" Plus Yeast
      The Effect of Vitamine. Seven rats per set. Weight on the first
      day: 178 5 76 For four days both A and B were fed on the regular
      diet. At the end of the fourth day: A 100 B 91 Both A and B were
      no...

-Appendix C. Review Of Recent Literature
      A survey of the literature during the past year reveals that two
      types of problems have been uppermost in the minds of
      investigators. One group were eager to add to our knowledge of
      rickets and pellag...
-Vitamines And Rickets
      On page 136 there is a sentence which reads that the consensus
      of opinion is that fat-soluble A is a vital factor in health,
      and that its absence in a diet is one of the causative factors
      in the deve...

-Difficulty Of Getting Diets Free From Vitamine A (Fat-Soluble A)
      Many workers, the author among them, have noticed that rats fed
      on a diet presumably free from vitamine A, grew for a
      considerable time before decline set in. This is in striking
      contrast to the rapid...
-The Nutritive Value Of Lard
      Ever since research on the vitamines began, lard has almost
      invariably been used in synthetic diets as a source of fat free
      from vitamine A. To explain the absence of this vitamine in lard
      has alway...

-Is Vitamine A Related To Animal And Vegetable Pigments?
      Dr. Steenbock was the first to suggest a relationship between
      pigments and vitamine A: wherever there were pigments,
      particularly such as are found in abundance in the plant world,
      there was vitamine ...
-Beriberi And Water-Soluble B (Vitamine B)
      The connection of beriberi and vitamine B is as close as ever,
      so that nothing that has been said on beriberi needs
      modification. Beriberi, writes Dr. Hess, is the main factor in
      the exceedingly hi...

-Scurvy And Water-Soluble C (Vitamine C)
      What has been said regarding the effect of heat and oxidation on
      vitamine A may now be repeated with respect to vitamine C (and
      probably with respect to vitamine B, though not so much work has
      been do...
-Vitamines And Plant Growth
      With the development of the subject of vitamines, attempts have
      been made to trace the origin of these elusive substances. It is
      now pretty well conceded that the animal cannot synthesize
      vitamines; a...

-Vitamines And Pellagra
      The etiology of pellagra still awaits solution. Some there are
      who still talk of its infectious origin; others, in larger
      numbers, talk of dietary deficiencies, among which proteins and
      vitamines loom...
-General References 2
      C. Funk: The Vitamines (Williams and Wilkins Co., Baltimore,
      1922). W. H. Eddy: The Vitamine Manual (Williams and Wilkins
      Co., Baltimore, 1921). H. C. Sherman: The Vitamins.
      Physiological Reviews,...

 
 

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